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Livres
Articles (48)
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The Perception of Materials through Oral Sensation

Howes, Philip D., Wongsriruksa, Supinya, Laughlin, Zoe, Witchel, Harry J., Miodownik, Mark, Bensmaia, Sliman J.

Journal:

PLoS ONE

Année:

2014

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2014

Design tools for interdisciplinary translation of material experiences

Wilkes, Sarah, Wongsriruksa, Supinya, Howes, Philip, Gamester, Richard, Witchel, Harry, Conreen, Martin, Laughlin, Zoe, Miodownik, Mark

Journal:

Materials & Design

Année:

2015

Langue:

english

Fichier:

PDF, 1.84 MB

english, 2015

[ACM Press the 36th European Conference - Utrecht, Netherlands (2018.09.05-2018.09.07)] Proceedings of the 36th European Conference on Cognitive Ergonomics - ECCE'18 - A trigger-substrate model for smiling during an automated formative quiz

Witchel, Harry J., Fagan, Patrick, Claxton, Harry L., Holmes, Daisy C., Ranji, Thomas T., Chalkley, Joe D., Santos, Carlos P., Westling, Carina E. I., Valstar, Michel F., Celuszak, Matt

Année:

2018

Langue:

english

Fichier:

PDF, 491 KB

english, 2018

Thigh-Derived Inertial Sensor Metrics to Assess the Sit-to-Stand and Stand-to-Sit Transitions in the Timed Up and Go (TUG) Task for Quantifying Mobility Impairment in Multiple Sclerosis

Witchel, Harry J., Oberndorfer, Cäcilia, Needham, Robert, Healy, Aoife, Westling, Carina E. I., Guppy, Joseph H., Bush, Jake, Barth, Jens, Herberz, Chantal, Roggen, Daniel, Eskofier, Björn M., Rashid,

Journal:

Frontiers in Neurology

Année:

2018

Langue:

english

Fichier:

PDF, 2.14 MB

english, 2018

Familial And Acquired Long QT Syndrome And The Cardiac Rapid Delayed Rectifier Potassium Current

Harry J Witchel, Jules C Hancox

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2000

Langue:

english

Fichier:

PDF, 445 KB

english, 2000

Time course and voltage dependence of expressed HERG current compared with native ”rapid” delayed rectifier K current during the cardiac ventricular action potential

J. C. Hancox, Allan J. Levi, Harry J. Witchel

Journal:

Pflügers Archiv European Journal of Physiology

Année:

1998

Langue:

english

Fichier:

PDF, 196 KB

english, 1998

Inhibition of ERK and JNK Decreases Both Osmosensitive Taurine Release and Cell Proliferation in Glioma Cells

Mark J. Belsey, Andrew R. L. Davies, Harry J. Witchel, Roland Z. Kozlowski

Journal:

Neurochemical Research

Année:

2007

Langue:

english

Fichier:

PDF, 370 KB

english, 2007

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

Anja G Teschemacher, Elizabeth P Seward, Jules C Hancox, Harry J Witchel

Journal:

British Journal of Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 257 KB

english, 1999

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

Ashok A Paul, Harry J Witchel, Jules C Hancox

Journal:

British Journal of Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 313 KB

english, 2002

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

James T Milnes, Olivia Crociani, Annarosa Arcangeli, Jules C Hancox, Harry J Witchel

Journal:

British Journal of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 254 KB

english, 2003

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin

Ari J Alexandrou, Rona S Duncan, Anneli Sullivan, Jules C Hancox, Derek J Leishman, Harry J Witchel, Joanne L Leaney

Journal:

British Journal of Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 331 KB

english, 2006

Acquired QT interval prolongation and HERG: implications for drug discovery and development

Keith Finlayson, Harry J. Witchel, James McCulloch, John Sharkey

Journal:

European Journal of Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 391 KB

english, 2004

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 °C: Cisapride versus dofetilide

James T. Milnes, Harry J. Witchel, Joanne L. Leaney, Derek J. Leishman, Jules C. Hancox

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2010

Langue:

english

Fichier:

PDF, 819 KB

english, 2010

Newly identified structurally disparate modulators of osmosensitive taurine efflux inhibit cell cycle progression

Mark J. Belsey, Steven J. Culliford, Richard M. Morley, Harry J. Witchel, Roland Z. Kozlowski

Journal:

European Journal of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 351 KB

english, 2003

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

Harry J. Witchel, James T. Milnes, John S. Mitcheson, Jules C. Hancox

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2002

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2002

Alteration of HERG Current Profile during the Cardiac Ventricular Action Potential, Following a Pore Mutation

Jules C. Hancox, Harry J. Witchel, Anthony Varghese

Journal:

Biochemical and Biophysical Research Communications

Année:

1998

Langue:

english

Fichier:

PDF, 119 KB

english, 1998

Inhibition of HERG Potassium Channel Current by the Class 1a Antiarrhythmic Agent Disopyramide

Ashok A. Paul, Harry J. Witchel, Jules C. Hancox

Journal:

Biochemical and Biophysical Research Communications

Année:

2001

Langue:

english

Fichier:

PDF, 106 KB

english, 2001

1-Methyladenine can consistently induce a fura-detectable transient calcium increase which is neither necessary nor sufficient for maturation in oocytes of the starfish Asterina miniata

Harry J. Witchel, Richard A. Steinhardt

Journal:

Developmental Biology

Année:

1990

Langue:

english

Fichier:

PDF, 771 KB

english, 1990

Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene—without QT interval prolongation

Kathryn H Yuill, John J Borg, John M Ridley, James T Milnes, Harry J Witchel, Ashok A Paul, Roland Z Kozlowski, Jules C Hancox

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 188 KB

english, 2004

High affinity HERG K+ channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656

John M. Ridley, James T. Milnes, Harry J. Witchel, Jules C. Hancox

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 482 KB

english, 2004

The N588K-HERG K+ channel mutation in the ‘short QT syndrome’: Mechanism of gain-in-function determined at 37 °C

Mark J. McPate, Rona S. Duncan, James T. Milnes, Harry J. Witchel, Jules C. Hancox

Journal:

Biochemical and Biophysical Research Communications

Année:

2005

Langue:

english

Fichier:

PDF, 338 KB

english, 2005

Erythromycin block of the HERG K+ channel: Accessibility to F656 and Y652

Rona S. Duncan, John M. Ridley, Christopher E. Dempsey, Derek J. Leishman, Joanne L. Leaney, Jules C. Hancox, Harry J. Witchel

Journal:

Biochemical and Biophysical Research Communications

Année:

2006

Langue:

english

Fichier:

PDF, 302 KB

english, 2006

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656

James T. Milnes, Harry J. Witchel, Joanne L. Leaney, Derek J. Leishman, Jules C. Hancox

Journal:

Biochemical and Biophysical Research Communications

Année:

2006

Langue:

english

Fichier:

PDF, 402 KB

english, 2006

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656

John M. Ridley, James T. Milnes, Rona S. Duncan, Mark J. McPate, Andrew F. James, Harry J. Witchel, Jules C. Hancox

Journal:

FEBS Letters

Année:

2006

Langue:

english

Fichier:

PDF, 402 KB

english, 2006

The use of standard electrode potentials to predict the taste of solid metals

Zoe Laughlin, Martin Conreen, Harry J. Witchel, Mark Miodownik

Journal:

Food Quality and Preference

Année:

2011

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2011

Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries

Alastair L Miller, Harry J Witchel, Jules C Hancox, Christopher L Jackson, Jamie Y Jeremy

Journal:

Metabolism

Année:

2004

Langue:

english

Fichier:

PDF, 268 KB

english, 2004

Lidoflazine is a high affinity blocker of the HERG K+channel

John M. Ridley, Philip C. Dooley, James T. Milnes, Harry J. Witchel, Jules C. Hancox

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2004

Langue:

english

Fichier:

PDF, 381 KB

english, 2004

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel

John M. Ridley, James T. Milnes, Jules C. Hancox, Harry J. Witchel

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2006

Langue:

english

Fichier:

PDF, 697 KB

english, 2006

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome

Mark J. McPate, Rona S. Duncan, Harry J. Witchel, Jules C. Hancox

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2006

Langue:

english

Fichier:

PDF, 126 KB

english, 2006

Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide

John M Ridley, James T Milnes, Andrew V Benest, Joe D Masters, Harry J Witchel, Jules C. Hancox

Journal:

Biochemical and Biophysical Research Communications

Année:

2003

Langue:

english

Fichier:

PDF, 210 KB

english, 2003

Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents

Harry J Witchel, Vijay K Pabbathi, Giovanna Hofmann, Ashok A Paul, Jules C Hancox

Journal:

FEBS Letters

Année:

2002

Langue:

english

Fichier:

PDF, 232 KB

english, 2002

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

James T Milnes, Christopher E Dempsey, John M Ridley, Olivia Crociani, Annarosa Arcangeli, Jules C Hancox, Harry J Witchel

Journal:

FEBS Letters

Année:

2003

Langue:

english

Fichier:

PDF, 382 KB

english, 2003

Drug-induced hERG Block and Long QT Syndrome

Harry J. Witchel

Journal:

Cardiovascular Therapeutics

Année:

2011

Langue:

english

Fichier:

PDF, 306 KB

english, 2011

Tryptophan depletion reverses the therapeutic effect of selective serotonin reuptake inhibitors in social anxiety disorder

Spilios V. Argyropoulos, Sean D. Hood, Mariona Adrover, Caroline J. Bell, Ann S. Rich, Jon R. Nash, Neil C. Rich, Harry J. Witchel, David J. Nutt

Journal:

Biological Psychiatry

Année:

2004

Langue:

english

Fichier:

PDF, 239 KB

english, 2004

The hERG potassium channel as a therapeutic target

Witchel, Harry J

Journal:

Expert Opinion on Therapeutic Targets

Année:

2007

Langue:

english

Fichier:

PDF, 606 KB

english, 2007

[ACM Press the 30th European Conference - Edinburgh, United Kingdom (2012.08.28-2012.08.31)] Proceedings of the 30th European Conference on Cognitive Ergonomics - ECCE '12 - Comparing four technologies for measuring postural micromovements during monitor engagement

Witchel, Harry J., Westling, Carina, Healy, Aoife, Chockalingam, Nachiappan, Needham, Rob

Année:

2012

Langue:

english

Fichier:

PDF, 382 KB

english, 2012

Short QT syndrome

McPate, Mark J, Witchel, Harry J, Hancox, Jules C

Journal:

Future Cardiology

Année:

2006

Langue:

english

Fichier:

PDF, 140 KB

english, 2006

Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome

Adeniran, Ismail, McPate, Mark J., Witchel, Harry J., Hancox, Jules C., Zhang, Henggui, McCulloch, Andrew D.

Journal:

PLoS Computational Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2011

[ACM Press the 31st European Conference - Toulouse, France (2013.08.26-2013.08.28)] Proceedings of the 31st European Conference on Cognitive Ergonomics - ECCE '13 - Mean head and shoulder heights when seated

Witchel, Harry J., Westling, Carina, Needham, Rob, Healy, Aoife, Chockalingam, Nachiappan

Année:

2013

Langue:

english

Fichier:

PDF, 493 KB

english, 2013

Psychotropic Drugs, Cardiac Arrhythmia, and Sudden Death

Witchel, Harry J., Hancox, Jules C., Nutt, David J.

Journal:

Journal of Clinical Psychopharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2003

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Zhang, Yihong, Colenso, Charlotte K., Harchi, Aziza El., Cheng, Hongwei, Witchel, Harry J., Dempsey, Chris E., Hancox, Jules C.

Journal:

Biochemical Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2016

Depleting Serotonin Enhances Both Cardiovascular and Psychological Stress Reactivity in Recovered Patients With Anxiety Disorders

Davies, Simon J.C., Hood, Sean D., Argyropoulos, Spilios V., Morris, Kelly, Bell, Caroline, Witchel, Harry J., Jackson, Peter R., Nutt, David J., Potokar, John P.

Journal:

Journal of Clinical Psychopharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 122 KB

english, 2006

[ACM Press the European Conference - Nottingham, United Kingdom (2016.09.05-2016.09.08)] Proceedings of the European Conference on Cognitive Ergonomics - ECCE '16 - Experience Design

Westling, Carina E.I., Ackah, James K., Santos, Carlos P., Chockalingam, Nachiappan, Witchel, Harry J.

Année:

2016

Langue:

english

Fichier:

PDF, 685 KB

english, 2016

[ACM Press the 2013 Inputs-Outputs Conference - Brighton, United Kingdom (2013.06.26-2013.06.26)] Proceedings of the 2013 Inputs-Outputs Conference on An Interdisciplinary Conference on Engagement in HCI and Performance - Inputs-Outputs '13 - Engagement: the inputs and the outputs

Witchel, Harry J.

Année:

2013

Langue:

english

Fichier:

PDF, 175 KB

english, 2013

[ACM Press the European Conference - Nottingham, United Kingdom (2016.09.05-2016.09.08)] Proceedings of the European Conference on Cognitive Ergonomics - ECCE '16 - The Complex Relationship Between Empathy, Engagement and Boredom

Witchel, Harry J., Santos, Carlos P., Ackah, James K., Tee, Julian, Chockalingam, Nachiappan, Westling, Carina E.I.

Année:

2016

Langue:

english

Fichier:

PDF, 676 KB

english, 2016

Non-Instrumental Movement Inhibition (NIMI) Differentially Suppresses Head and Thigh Movements during Screenic Engagement: Dependence on Interaction

Witchel, Harry J., Santos, Carlos P., Ackah, James K., Westling, Carina E. I., Chockalingam, Nachiappan

Journal:

Frontiers in Psychology

Année:

2016

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2016

The self-assessment dilemma: an open-source, ethical method using Matlab to formulate multiple-choice quiz questions for online reinforcement

Witchel, Harry J., Guppy, Joseph H., Smith, Claire F.

Journal:

AJP Advances in Physiology Education

Année:

2018

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2018

Compliant activity rather than difficulty accelerates thought probe responsiveness and inhibits deliberate mind wandering

Subhani, Benjamin R., Amos-Oluwole, Oluwademilade I., Claxton, Harry L., Holmes, Daisy C., Westling, Carina E. I., Witchel, Harry J.

Journal:

Behaviour & Information Technology

Année:

2019

Langue:

english

Fichier:

PDF, 2.06 MB

english, 2019